What Should I Expect During a Ketamine Therapy Session?


Ketamine therapy is increasingly becoming recognized as a powerful treatment for depression, PTSD, anxiety, and even chronic pain. While starting a new treatment journey can feel both exciting and overwhelming or daunting, having the right information can make all the difference.
If you’re considering Ketamine-Assisted Therapy (KAT) and wondering what to expect, this guide will walk you through the entire process - helping you feel informed, comfortable, and reassured every step of the way.
1. Pre-Treatment Preparation: Setting the Stage
Before your first ketamine therapy session, you’ll have an initial consultation with a healthcare provider. This step determines if ketamine therapy is the safe and appropriate option for you. Your provider will review your medical history, mental health condition, and any medications you’re taking. It is a collaborative opportunity for you to ask your questions, express any concerns, and get a clearer picture of what to expect.
How to Prepare for Your Session:
(Your provider will give you specific instructions but here are some general guidelines you might want to be aware of)
- Avoid eating for 4-6 hours before your appointment to reduce nausea.
- Stay hydrated but limit fluid intake 2 hours before treatment.
- Wear comfortable clothing.
- Arrange for transportation home, as you may feel drowsy after the session.
- Set an intention for your session - this will help guide your experience.
2. Arrival and Pre-Treatment Assessment
Once you’ve been approved for treatment & arrive at the clinic, a healthcare provider will check your vital signs, including blood pressure and heart rate. You’ll then be guided to a calm, private treatment room designed to promote relaxation.
Some clinics may offer an eye mask, noise-canceling headphones, or a curated playlist to help you stay focused and comfortable during the session. Before then your provider may have given you some simple but important preparation guidelines - things like what to eat (or not eat) before your session, how to set intentions, and what to expect during the experience.
Following these steps can help you get the most out of the treatment. It’s really about creating a calm, supportive space where your mind can do the work.
3. The Administration of Ketamine
Ketamine can be administered in different ways, depending on the clinic and your treatment plan. The most common methods include:
- Intravenous (IV) Infusion: A slow, controlled dose of ketamine delivered through an IV drip (typically lasting 40-60 minutes).
- Intramuscular (IM) Injection: A single-dose injection into the muscle (lasting 30-45 minutes).
- Nasal Spray (Esketamine/Spravato): A self-administered spray under medical supervision (lasting 2 hours).
- Lozenges: Dissolvable tablets used in some at-home treatment protocols (lasting 60-90 minutes).
4. The Ketamine Experience: What It Feels Like
Once the ketamine takes effect, you may experience:
- A sense of detachment: Many patients describe feeling like they are floating or outside their body (dissociation).
- Changes in perception: You might see colors, patterns, or feel a dream-like state.
- Emotional release: Some people experience deep emotions or insights related to their mental health.
- Mild physical effects: These can include dizziness, nausea, or increased heart rate, but they typically subside quickly.
Throughout the session, a medical professional will monitor you to ensure safety and comfort.
5. Post-Treatment Recovery: Coming Back to Baseline
After your session, you’ll spend some time in a recovery area while the effects wear off (usually within a few hours). You may feel groggy or introspective, so clinics often recommend taking the rest of the day to rest and reflect.
What to Expect Post-Treatment:
- Some lingering dissociation or dizziness.
- A gradual return to full awareness within a few hours.
- Emotional shifts - some patients feel immediate relief, while others notice gradual improvements over several days.
- The need for integration: Journaling or speaking with a licensed therapist (ususally from your provider) about your experience can help process insights gained during the session.
6. Follow-Up and Next Steps
Ketamine therapy is usually not a one-time treatment. Most patients undergo a series of sessions over several weeks. Your provider will work with you to assess progress and determine the best ongoing treatment plan for you.
Many people report mood improvements within hours to days, with lasting benefits increasing over multiple sessions. The point of this ongoing support is to help translate your therapeutic experience into meaningful, lasting progress.
Is Ketamine Therapy Right for You?
Ketamine-Assisted Therapy offers hope for those struggling with treatment-resistant mental health conditions. While each person’s experience is unique, knowing what to expect can help you feel prepared and at ease.
If you’re considering ketamine therapy, consult with a licensed provider to see if it’s the right option for you. Ketamine therapy has shown promise for individuals struggling with treatment-resistant conditions like depression, anxiety, and PTSD, especially since traditional treatments don’t seem to be working anymore. However, it's essential to consider your unique medical history and personal circumstances.
If you’re curious about whether KAT might be right for you, consider reaching out to a qualified provider. Being informed is the first step toward making the best decision for your mental health.
For expert guidance on safe and effective ketamine therapy treatment, contact Enthea today. Our team is committed to providing access to innovative mental health care tailored to your needs.